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Chair

Research Interests:

• Molecular mechanisms of DNA damage response and repair pathways in genome maintenance and tumor suppression
• Proteomic analysis of oncogenic and tumor suppressive pathways
• Investigation of gene-gene and gene-drug interactions involved in cancer development and therapy

Chen Laboratory

His lab studies metabolic stress-induced cell death, particularly ferroptosis, in cancer. Currents efforts aim to study:

• The role and mechanisms of ferroptosis (a form of cell death induced by lipid peroxidation) in tumor suppression and how to target ferroptosis in cancer therapy
• The role of cystine transporter SLC7A11 in the regulation of nutrient dependency and targeting its associated metabolic vulnerabilities in cancer therapy

Gan Laboratory

Research Interests:

• Developing and applying cutting-edge mass spectrometry approaches to identify hitherto unknown signaling proteins and ligands and resolve the cascades of localized phosphorylation events in checkpoint signaling

Kalocsay?Laboratory

Research Interests:

• Inhibition of LMW forms of cyclin E as a therapeutic target in combination therapy for triple negative breast cancer
• Delineation of how the alteration of cyclin E, a G1 cyclin, could lead to the tumorigenic phenotype and determination of the oncogenic potential of the altered forms of cyclin E in breast cancer
  
• Determination of the mechanism of action of intracellular elastase and its inhibitor elafin in tumorigenesis and subsequent metastasis
• Examination of mechanisms of action and resistance to CDK4/6 inhibitors in ER positive breast cancer patients
  
• Identification of novel treatment strategies, targeting the cell cycle, for soft-tissue sarcomas
  

                                               Keyomarsi and Hunt Laboratory

Research Interests:

• Discovery and rigorous characterization of non-coding RNA functions in normal physiology, cancer, and metastasis
• Identification of deubiquitinating enzymes as antitumor and anti-metastatic targets
  
• Decoding the roles of developmental regulators in the development, metastasis, and response to therapy of cancer and other diseases

Ma Laboratory

Research Interests:

• Pancreatic and lung cancer:  the leading causes of cancer death
• Adoptive immunotherapy: CAR T cell-based therapy development
• Biochemistry: novel and "orphan" enzymes substrates discovery
• Genetics: CRISPR/Cas9 animal models for cancer pharmacogenomic

Mazur Laboratory

Research Interests:

• The effects of radiation and chemotherapy on male germ cells
• Fertility preservation for boys and young men undergoing cancer therapy

Meistrich/Shetty Laboratory

The overarching goal of his research program is to understand the mechanisms of tissue regeneration and tumorigenesis by employing genetically engineered mice and organoids and to specifically answer two critical questions:

• Is tumor cell plasticity a therapeutic vulnerability of cancer?
• Can manipulating cell plasticity promote tissue regeneration, or even prevent tissue damage?

Park Laboratory

Research Interests:

• Identifying and targeting drivers of breast cancer metastasis
• Identifying and targeting vulnerabilities in treatment-refractory primary TNBC
• Defining features that enable indolent breast cancer to advance to aggressive disease
• Elucidating how fasting and different diets protect small intestinal stem cells from lethal doses of chemotherapy and radiation therapy

H Piwnica-Worms Laboratory

Research Interests:

• Understand how oncogenic signaling pathways and tumor microenvironment regulate cancer development and metastasis
• Â鶹ӳ»­ for biomarkers and context-specific therapeutic targets for personalized cancer medicine
  

Zhao Laboratory

Division Head, Radiation Oncology Department Chair

Koong Laboratory

Phuoc Tran, M.D., Ph.D.
Chair, Genitourinary Radiation Oncology

Cho Laboratory

Colbert Laboratory

Grosshans Laboratory

Jiang Laboratory

Klopp Laboratory

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Lin Laboratory

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Sawakuchi and Shaitelman Laboratory

Schrank Laboratory

Sawakuchi and Shaitelman Laboratory

Spiotto Laboratory

Welsh Laboratory

Woodward Laboratory