Current Research
Immune surveillance of aneuploid cells: How does the immune system recognize genome-imbalanced cells?
Aneuploidy creates profound cellular stress and abnormal gene expression that can alert the immune system. We investigate how innate and adaptive immune cells sense and respond to aneuploid cells in vivo. Using conditional mouse models that induce chromosome missegregation, together with immune profiling and single-cell analyses, we aim to define the pathways that trigger recognition and elimination of aneuploid cells before malignant transformation.
Mechanisms of immune evasion in aneuploid tumors: Why do highly aneuploid tumors escape immunity?
Despite strong immunogenic potential, aneuploid tumors often survive in immune-competent environments. We explore how chronic chromosomal instability reshapes antigen presentation, interferon signaling and the immunoproteasome machinery. Our goal is to identify how tumors suppress immune detection and to pinpoint vulnerabilities that can be targeted to reactivate anti-tumor immunity.
Single-cell genomics of chromosomal instability: Mapping the immune-tumor ecosystem at single-cell resolution
Every aneuploid tumor is a mosaic of cells with distinct chromosomal imbalances. We apply single-cell DNA and RNA sequencing to construct integrated atlases that link karyotype changes to transcriptional states and immune interactions. By resolving how genome instability sculpts tumor heterogeneity and the surrounding microenvironment, we aim to uncover predictive markers of immune suppression and therapeutic response.