Reshaping the gut microbiome can boost chemotherapy delivery to tumors
Nanoparticle-based chemotherapy is widely used but liver clearance often limits its effectiveness?
The gut microbiome regulates how aggressively the liver clears these drugs from the bloodstream
A common antibiotic reshaped gut bacteria in preclinical models, significantly reducing liver clearance and doubling how long chemotherapy remained in circulation to reach tumors
The findings demonstrate that...
Immune signals may help explain, predict responses to therapies for difficult-to-treat depression
Treatment-resistant depression occurs when symptoms persist after multiple antidepressant treatments
Rapid-acting antidepressants, such as ketamine...
Targeting a signaling pathway activated by acidic tumor environment restores treatment response to PARP inhibitors in ovarian cancer
PARP inhibitors are among the most widely used therapies for ovarian cancer, but their long-term effectiveness is limited by acquired resistance...
Donor cord blood composition may influence CAR NK cell therapy outcomes
CAR NK cell therapy is a novel immunotherapy made from natural killer (NK) cells engineered to better recognize and eliminate cancer cells
At UT MD Anderson, CAR NK cell therapies are created from NK cells collected from donated umbilical cord blood?
UT MD Anderson researchers identified a small population of immature NK cells associated with poorer treatment outcomes
These immature cells can pick up cancer proteins through a process...
Early inflammation signal drives oral cancer development, highlights path for immunoprevention
Researchers identified immune changes in a subset of oral precancerous lesions that may be at higher risk for cancer progression
Cells with...
Immune cells use previously unknown pathway to eliminate AML
Researchers identified a previously unknown way in which T cells can attack acute myeloid leukemia (AML) cells, even when the AML cells evade...
Immune ecotypes may explain multiple myeloma outcomes missed by disease staging
Researchers mapped immune cells and their interactions across multiple myeloma and its precursor conditions
The study identified five tumor...
Novel CAR T cell therapy offers promising option for hard-to-treat kidney cancer
Clear cell renal cell carcinoma (ccRCC) is the most common form of kidney cancer, and patients who progress on standard therapies have limited...
Epigenetic therapy shows promise against treatment-resistant AML
Next-generation epigenetic therapy showed stronger anti-leukemia activity than current standard treatments in preclinical models of acute...
KRAS-targeting drugs show promise for rare appendix cancer
KRAS is the most common genetic mutation in appendix cancer, occurring in approximately 80% of mucinous tumors, the most common subtype
KRAS-targeted...
Experimental cell therapy delivers encouraging results for patients with rare, potentially fatal brain infection
No approved treatments exist for progressive multifocal leukoencephalopathy (PML), a serious neurological condition caused by the JC virus...
Fasting primes gut microbiome to improve intestinal recovery after radiation treatment
Researchers identified a gut bacterium that helps prime intestinal stem cells for faster recovery
In preclinical models, short-term...
Microscopic colorectal cancer liver metastases harbor features that enable cancer cells to survive treatment and drive disease recurrence
Researchers...
Scientists develop new, improved method to find and isolate the strongest cancer-fighting immune cells
Isolating immune cells that can best identify and attack cancer cells is challenging because these cells are rare within tumors
Researchers...
Novel antibody-drug conjugate eliminates residual cancer cells in majority of patients with B-cell ALL
Seventy percent of patients had residual levels of cancer cells eliminated
Clearing residual cancer cells is a strong predictor...
Scientists uncover why some patients with rare leukemia may not benefit from approved targeted therapy
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive form of acute leukemia
Tagraxofusp is the first approved therapy...
New study identifies genetic markers that could guide emerging prostate cancer treatments
Ferroptosis is a type of cell death that has emerged as a promising avenue to target cancers that are resistant to current therapies
This study...
Biomarker-guided drug combinations may improve outcomes in treatment-resistant melanoma
In a preclinical study, adding a BCL2 inhibitor to standard melanoma therapy shrank tumors that had stopped responding to therapy
The study...