New simulation framework DKOsim advances CRISPR-based gene to gene interaction research
Double-CRISPR Knockout?Simulation (DKOsim)?is a computer-based ¡°virtual lab¡± that simulates genomic?experiments? Studying how genes interact in real cells is difficult,?expensive?and often produces uncertain results DKOsim?allows researchers to test ideas and methods using realistic controlled data while designing more reliable real-world experiments
Researchers?at?The University...
Researchers identify how enzyme affects infertility and cancer progression
Researchers used preclinical models to identify how changes to the Dicer enzyme affect both infertility and cancer progression
The study identified...
Novel combination therapy yields high response rates in early-stage classical Hodgkin lymphoma
Phase 2 trial evaluated abbreviated chemotherapy?plus brentuximab vedotin and nivolumab
Combination?achieved complete response in&...
Imaging tool reveals novel insights into DNA replication stress response
Reversed DNA replication forks protect against stress to maintain genomic stability and serve as central components to cancer resistance, disease suppression, aging and immunotherapy response
Researchers developed the RF-SIRF imaging tool to map reversed forks with single-cell resolution and within their native cell environment
RF-SIRF highlighted unique epigenetic signals that provide insights into how cells respond to replication stress...
Novel tool more accurately predicts risk of Li-Fraumeni Syndrome
In a prospective validation study, researchers at Â鶹ӳ» MD Anderson Cancer Center demonstrated that a new mathematical model...
FLAG-based regimen delivers strong outcomes in subtype of acute myeloid leukemia
Highest reported five-year,?relapse-free survival?and overall survival?rates, especially with FLAG-GO??
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AACR: Novel approach prevents cancer progression, spares surgery for majority of patients with precancerous oral lesions
Precancerous oral lesions can progress to oral cancer and are typically ablated or surgically removed as a preventive measure
Direct injection...
AACR: New platform uses machine learning to predict responses in patients with lung cancer
Path-IO is a machine learning platform that incorporates pathology data to predict how patients with non-small cell lung cancer will respond...
AACR: Zedoresertib and lunresertib combination shows promising antitumor activity
Phase I trial provides early clinical proof-of-concept supporting the combination of zedoresertib and lunresertib in certain advanced solid...
AACR: Clinical trial presentations feature advances across cancer care
Early results for first-in-human and first-in-class therapies including an integrin inhibitor and a genetically engineered tumor infiltrating...
First-line targeted therapy shows antitumor activity in patients with advanced lung cancer
First-line?zongertinib?showed antitumor activity in?treatment-na?ve patients with advanced or metastatic?HER2-mutant ...
AACR: UT MD Anderson shares latest breakthroughs in cancer research
ABSTRACTS:?NG05, 1296, 1297, 1361, 1366, 2709, 3451, 4010, 4020, 4033, 4053, 6724, 6743, 6761, 6788, 6803
Researchers from The...
Researchers find new target to sensitize pancreatic tumors to immunotherapy
DPY30 acts as an epigenetic regulator to help pancreatic tumors maintain genomic stability
Targeting DPY30 triggers immune cell infiltration...
Study identifies strategy to overcome radiation therapy resistance in lung cancer
These results show how mitochondrial enzyme dihydroorotate dehydrogenase contributes to radiation therapy resistance
Researchers were able to...
Researchers identify blood-based biomarker for cancer risk in people with Lynch Syndrome
Lynch Syndrome (LS) is a hereditary condition involving mutations in DNA mismatch repair genes
Researchers sequenced T cell receptors in blood...
Radiation therapy improves outcomes for 'supermassive¡¯ bile duct tumors
Patient outcomes were significantly better?when treated with radiation therapy?plus?standard-of-care chemotherapy?
First-in-class radio-theranostic utilizes novel antibody developed at UT MD Anderson
Study details the development of a novel antibody that targets a specific type of B7-H3, a protein overexpressed in many cancers?
Combination treatment benefits patients with advanced breast cancer that has spread to brain
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Leptomeningeal metastasis?occurs?when cancer spreads to the thin layers of?tissue?and fluid that surround...
Dual targeting approach improves immunotherapy response in glioblastoma
Researchers from Â鶹ӳ» MD Anderson Cancer Center have found that simultaneously blocking two key ¡°don¡¯t eat me signals¡±...
Low testosterone levels may be associated with increased risk of prostate cancer progression during surveillance
Study found men with low?testosterone?levels?were?associated with a?60%?higher likelihood that prostate cancer...
New biomarker predicts chemotherapy response in triple-negative breast cancer
Patients with triple-negative breast cancer have different treatment responses
Computational tools that predict treatment response historically...
Antibody-drug conjugate achieves high response rates as frontline treatment in aggressive, rare blood cancer
Phase II study evaluates treatment for patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN), a rare, aggressive blood cancer
The...
Biomarkers predict patients with glioblastoma who will survive longer after treatment with cancer-targeting virus
Glioblastoma is a deadly brain cancer that suppresses the immune system and doesn¡¯t respond well to available therapies
Researchers engineered...
First-in-human study finds novel immune cell therapy is safe and effective in advanced lymphoma
The novel cell therapy, called RB-1355, appears safe and well tolerated
RB-1355 offers unique advantages, such as being ready in about one week...
Americans prefer to screen for cervical cancer in-clinic vs. at home
More than 60% of American women prefer to get their cervical cancer screening in a clinic versus at home with a self-sampling kit, study finds...
Study shows strong evidence for effectiveness of metastasis-directed radiation therapy in prostate cancer
Metastasis-directed therapy (MDT) significantly improved progression-free survival and later endpoints
Data indicate statistically significant...
Blood biomarker points to increased risk of brain metastasis in patients with inflammatory breast cancer
Brain metastases are a common complication of inflammatory breast cancer
High levels of soluble E-cadherin in the blood are associated with...
Study reveals synergistic effect of CDK2 and CDK4/6 combination therapy
This preclinical study explains the mechanism underlying CDK2 and CDK4/6 combination therapy, providing a blueprint for future clinical use...
Engineered nanobodies improved respiratory defenses in preclinical study
There are no current therapies designed to improve protection against multiple different respiratory viruses
Engineered nanobodies improved...
Immune-targeting vaccine shows promise intercepting cancer in patients with Lynch Syndrome
Lynch Syndrome significantly increases the lifetime risk of developing multiple cancers, including colorectal and endometrial ?
NOUS-209...
New treatment combination offers excellent results for early-stage Hodgkin lymphoma with less chemotherapy
More than 90% of patients had a complete response to novel treatment combination?
After two years, 97% of patients remained...
Novel immunotherapy demonstrates early potential to overcome resistance to immune checkpoint therapy
Linavonkibart, also known as SRK-181, is an experimental therapy from Scholar Rock that aims to prevent or overcome resistance to immune checkpoint...
Mutation predicts chemotherapy resistance and better responses to immunotherapy in advanced bladder cancer
Researchers studied the KDM6A gene, which is altered in about 26% of advanced bladder cancers
Tumors with KDM6A mutations did not respond well...
Higher bacteria levels inside tumors can promote immunotherapy resistance in head and neck cancer
Researchers found that the amount, and not?the?type, of bacteria inside?tumors can predict response to treatment?in lab...
Dual-antigen targeting of large B-cell lymphoma shows promise in reducing relapse
Large B-cell lymphoma (LBCL) is an aggressive blood cancer with few?treatment?options
CAR?T cell therapy targeting...
Immunotherapy before and after surgery improved outcomes in lung cancer patients with lymph node metastases
Perioperative?nivolumab?plus?neoadjuvant?chemotherapy?improved?outcomes for?patients?regardless of...
Immunotherapy combination does not improve outcomes for patients with advanced anal cancer
Phase II?ETCTN?trial?found?ipilimumab plus nivolumab?did not improve?outcomes?over nivolumab alone?in...
Researchers identify novel therapeutic target to improve recovery after nerve injury
Peripheral nerve injury reduces the ability of macrophages to clear dead or dying cells ¨C a process known as efferocytosis ¨C leading to chronic...
High levels of protein drive tumor immune suppression in head and neck cancer
BATF2 is a new type of tumor suppressor that can be epigenetically silenced by high levels of glutamine in the tumor microenvironment
Glutamine...
Targeted therapy plus immunotherapy improved outcomes in advanced metastatic colorectal cancer
Phase III?COMMIT?trial evaluated better first-line options for patients with?dMMR/MSI-H metastatic colorectal cancer
The study...
Circadian rhythms may affect risk of bacterial infection
Researchers identified an inflammation biomarker in laboratory model that predicts which individuals are at an increased risk of bacterial infection...