Reshaping the gut microbiome can boost chemotherapy delivery to tumors
Nanoparticle-based chemotherapy is widely used but liver clearance often limits its effectivenessÂ
The gut microbiome regulates how aggressively the liver clears these drugs from the bloodstream
A common antibiotic reshaped gut bacteria in preclinical models, significantly reducing liver clearance and doubling how long chemotherapy remained in circulation to reach tumors
The findings demonstrate that...
Targeting a signaling pathway activated by acidic tumor environment restores treatment response to PARP inhibitors in ovarian cancer
PARP inhibitors are among the most widely used therapies for ovarian cancer, but their long-term effectiveness is limited by acquired resistance...
Epigenetic therapy shows promise against treatment-resistant AML
Next-generation epigenetic therapy showed stronger anti-leukemia activity than current standard treatments in preclinical models of acute...
Fasting primes gut microbiome to improve intestinal recovery after radiation treatment
Researchers identified a gut bacterium that helps prime intestinal stem cells for faster recovery
In preclinical models, short-term fasting increased the population of this bacterium, helping the small intestine regenerate more effectively after radiation treatment
The findings could lead to dietary or microbe-based strategies to reduce side effects of cancer radiation therapy
A new preclinical study from...
Biomarker-guided drug combinations may improve outcomes in treatment-resistant melanoma
In a preclinical study, adding a BCL2 inhibitor to standard melanoma therapy shrank tumors that had stopped responding to therapy
The study...
Study identifies a new cause of age-related inflammation, suggesting promising treatment pathway
As cells age, they increasingly export nucleic acid structures called R-loops from the nucleus, triggering an immune response that causes...