Di Pilato Laboratory
Mauro Di Pilato, Ph.D.
Principal Investigator
Areas of Research
- Immunology
- Immunotherapy
- Tumor Microenvironment
At the Di Pilato Laboratory, we are driven to uncover the vital roles that specific immune cells play within tumors. Our focus is to unravel how antigen-presenting cells influence tumor progression and shape T cell responses against cancer. We are determined to understand why some cancer patients do not respond to current immunotherapies. Through cutting-edge discovery science, we aim to pioneer innovative strategies that improve treatment outcomes and significantly enhance quality of life for these patients.
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Our Research
Our discovery laboratory is dedicated to unraveling the fundamental cellular interactions within the tumor microenvironment, with a special focus on CCR7+ dendritic cells and the specific molecules they use to regulate T cell responses. By leveraging innovative mouse models and human cancer specimens, we strive to uncover novel strategies to regulate T cell accumulation and develop approaches that boost the effectiveness of cancer immunotherapy.