Immunobiology and Tumor Microenvironment Program Publications

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ITM High-Impact Publications

Andrews MC, Duong CPM, Gopalakrishnan V, Iebba V, Chen WS, Derosa L, Khan MAW, Cogdill AP, White MG , Wong MC, Ferrere G, Fluckiger A, Roberti MP, Opolon P, Alou MT, Yonekura S, Roh W, Spencer CN, Curbelo IF, Vence L, Reuben A , Johnson S, Arora R, Morad G, Lastrapes M, Baruch EN, Little L, Gumbs C, Cooper ZA, Prieto PA, Wani K, Lazar AJ , Tetzlaff MT , Hudgens CW, Callahan MK, Adamow M, Postow MA, Ariyan CE, Gaudreau PO, Nezi L, Raoult D, Mihalcioiu C, Elkrief A, Pezo RC, Haydu LE, Simon JM, Tawbi HA , McQuade J , Hwu P , Hwu WJ, Amaria RN , Burton EM, Woodman SE , Watowich S , Diab A , Patel SP , Glitza IC , Wong MK , Zhao L, Zhang J, Ajami NJ, Petrosino J, Jenq RR , Davies MA , Gershenwald JE , Futreal PA , Sharma P , Allison JP , Routy B, Zitvogel L, Wargo JA .  Nat Med. 2021; 27(8):1432-1441. PubMed ID:34239137; PMCID:PMC11107795.
Chu Y, Dai E, Li Y, Han G, Pei G, Ingram DR, Thakkar K, Qin JJ, Dang M, Le X , Hu C, Deng Q, Sinjab A, Gupta P, Wang R, Hao D, Peng F, Yan X, Liu Y, Song S , Zhang S, Heymach JV , Reuben A , Elamin YY , Pizzi MP, Lu Y , Lazcano R, Hu J, Li M, Curran M , Futreal A , Maitra A , Jazaeri AA , Ajani JA , Swanton C, Cheng XD, Abbas HA , Gillison M , Bhat K , Lazar AJ , Green M , Litchfield K, Kadara H , Yee C , Wang L .  Nat Med. 2023; 29(6):1550-1562. PubMed ID:37248301; PMCID:PMC11421770.
Gao J , Navai N , Alhalabi O , Siefker-Radtke A , Campbell MT , Tidwell RS, Guo CC, Kamat AM , Matin SF , Araujo JC , Shah AY , Msaouel P , Corn P , Wang J , Papadopoulos JN, Yadav SS, Blando JM, Duan F, Basu S, Liu W, Shen Y , Zhang Y, Macaluso MD, Wang Y, Chen J, Zhang J, Futreal A , Dinney C , Allison JP , Goswami S , Sharma P .  Nat Med. 2020; 26(12):1845-1851. PubMed ID:33046869; PMCID:PMC9768836.
Goswami S , Walle T, Cornish AE, Basu S, Anandhan S, Fernandez I, Vence L, Blando J, Zhao H, Yadav SS, Ott M, Kong LY, Heimberger AB , de Groot J, Sepesi B , Overman M , Kopetz S , Allison JP , Pe'er D, Sharma P.  Nat Med. 2020; 26(1):39-46. PubMed ID:31873309; PMCID:PMC7182038.
Wang R, Dang M, Harada K, Han G, Wang F, Pool Pizzi M, Zhao M, Tatlonghari G, Zhang S, Hao D, Lu Y , Zhao S, Badgwell BD , Blum Murphy M , Shanbhag N, Estrella JS, Roy-Chowdhuri S , Abdelhakeem AAF, Wang Y, Peng G , Hanash S , Calin GA , Song X, Chu Y, Zhang J, Li M, Chen K , Lazar AJ , Futreal A , Song S , Ajani JA , Wang L .  Nat Med. 2021; 27(1):141-151. PubMed ID:33398161; PMCID:PMC8074162.
Han G, Sinjab A, Rahal Z, Lynch AM, Treekitkarnmongkol W, Liu Y, Serrano AG, Feng J, Liang K, Khan K, Lu W, Hernandez SD, Liu Y, Cao X, Dai E, Pei G, Hu J, Abaya C, Gomez-Bolanos LI, Peng F, Chen M, Parra ER, Cascone T , Sepesi B , Moghaddam SJ , Scheet P , Negrao MV , Heymach JV , Li M, Dubinett SM, Stevenson CS, Spira AE, Fujimoto J , Solis LM, Wistuba II , Chen J , Wang L , Kadara H .  Nature. 2024; 627(8004):656-663. PubMed ID:38418883; PMCID:PMC10954546.
Helmink BA , Reddy SM, Gao J , Zhang S, Basar R , Thakur R, Yizhak K, Sade-Feldman M, Blando J, Han G, Gopalakrishnan V, Xi Y, Zhao H, Amaria RN , Tawbi HA , Cogdill AP, Liu W, LeBleu VS, Kugeratski FG, Patel S , Davies MA , Hwu P , Lee JE , Gershenwald JE , Lucci A , Arora R, Woodman S , Keung EZ , Gaudreau PO, Reuben A , Spencer CN, Burton EM, Haydu LE, Lazar AJ , Zapassodi R, Hudgens CW, Ledesma DA, Ong S, Bailey M, Warren S, Rao D, Krijgsman O, Rozeman EA, Peeper D, Blank CU, Schumacher TN, Butterfield LH, Zelazowska MA, McBride KM , Kalluri R , Allison J , Petitprez F, Fridman WH, Saut��s-Fridman C, Hacohen N, Rezvani K , Sharma P , Tetzlaff MT , Wang L , Wargo JA .  Nature. 2020; 577(7791):549-555. PubMed ID:31942075; PMCID:PMC8762581.
Vellano CP, White MG , Andrews MC, Chelvanambi M, Witt RG, Daniele JR, Titus M , McQuade JL , Conforti F, Burton EM, Lastrapes MJ, Ologun G, Cogdill AP, Morad G, Prieto P, Lazar AJ , Chu Y, Han G, Khan MAW, Helmink B , Davies MA , Amaria RN , Kovacs JJ, Woodman SE , Patel S , Hwu P , Peoples M, Lee JE , Cooper ZA, Zhu H, Gao G, Banerjee H, Lau M, Gershenwald JE , Lucci A , Keung EZ , Ross MI , Pala L, Pagan E, Segura RL, Liu Q, Borthwick MS, Lau E, Yates MS , Westin SN , Wani K, Tetzlaff MT , Haydu LE, Mahendra M, Ma X, Logothetis C , Kulstad Z, Johnson S, Hudgens CW, Feng N, Federico L, Long GV, Futreal PA , Arur S , Tawbi HA , Moran AE, Wang L , Heffernan TP , Marszalek JR, Wargo JA .  Nature. 2022; 606(7915):797-803. PubMed ID:35705814; PMCID:PMC10071594.
Spencer CN, McQuade JL , Gopalakrishnan V, McCulloch JA, Vetizou M, Cogdill AP, Khan MAW, Zhang X, White MG , Peterson CB , Wong MC, Morad G, Rodgers T, Badger JH, Helmink BA , Andrews MC, Rodrigues RR, Morgun A, Kim YS, Roszik J, Hoffman KL, Zheng J, Zhou Y, Medik YB, Kahn LM, Johnson S, Hudgens CW, Wani K, Gaudreau PO, Harris AL, Jamal MA, Baruch EN, Perez-Guijarro E, Day CP, Merlino G, Pazdrak B, Lochmann BS, Szczepaniak-Sloane RA, Arora R, Anderson J, Zobniw CM, Posada E, Sirmans E, Simon J, Haydu LE, Burton EM, Wang L , Dang M, Clise-Dwyer K, Schneider S, Chapman T, Anang NAS, Duncan S, Toker J, Malke JC, Glitza IC , Amaria RN , Tawbi HA , Diab A , Wong MK , Patel SP , Woodman SE , Davies MA , Ross MI , Gershenwald JE , Lee JE , Hwu P , Jensen V, Samuels Y, Straussman R, Ajami NJ, Nelson KC , Nezi L, Petrosino JF, Futreal PA , Lazar AJ , Hu J, Jenq RR , Tetzlaff MT, Yan Y, Garrett WS, Huttenhower C, Sharma P , Watowich SS , Allison JP , Cohen L , Trinchieri G, Daniel CR , Wargo JA .  Science. 2021; 374(6575):1632-1640. PubMed ID:34941392; PMCID:PMC8970537.
Carugo A, Minelli R, Sapio L, Soeung M, Carbone F, Robinson FS, Tepper J, Chen Z, Lovisa S, Svelto M, Amin S, Srinivasan S, Del Poggetto E, Loponte S, Puca F, Dey P, Malouf GG, Su X , Li L, Lopez-Terrada D, Rakheja D, Lazar AJ , Netto GJ, Rao P, Sgambato A, Maitra A , Tripathi DN, Walker CL, Karam JA , Heffernan TP , Viale A , Roberts CWM, Msaouel P , Tannir NM , Draetta GF , Genovese G .  Cancer Cell. 2019; 35(2):204-220.e9. PubMed ID:30753823; PMCID:PMC7876656.
Wang R, Song S , Qin J, Yoshimura K, Peng F, Chu Y, Li Y, Fan Y, Jin J, Dang M, Dai E, Pei G, Han G, Hao D, Li Y, Chatterjee D, Harada K, Pizzi MP, Scott AW, Tatlonghari G, Yan X, Xu Z, Hu C, Mo S, Shanbhag N, Lu Y , Sewastjanow-Silva M, Fouad Abdelhakeem AA, Peng G , Hanash SM , Calin GA , Yee C , Mazur P , Marsden AN, Futreal A , Wang Z, Cheng X, Ajani JA , Wang L .  Cancer Cell. 2023; 41(8):1407-1426.e9. PubMed ID:37419119; PMCID:PMC10528152.
Hayase E, Hayase T, Jamal MA, Miyama T, Chang CC, Ortega MR, Ahmed SS, Karmouch JL, Sanchez CA, Brown AN, El-Himri RK, Flores II, McDaniel LK, Pham D, Halsey T, Frenk AC, Chapa VA, Heckel BE, Jin Y, Tsai WB, Prasad R, Tan L, Veillon L, Ajami NJ, Wargo JA , Galloway-Pe?a J, Shelburne S , Chemaly RF , Davey L, Glowacki RWP, Liu C, Rondon G , Alousi AM , Molldrem JJ , Champlin RE , Shpall EJ , Valdivia RH, Martens EC, Lorenzi PL , Jenq RR .  Cell. 2022; 185(20):3705-3719.e14. PubMed ID:36179667; PMCID:PMC9542352.
Morad G, Helmink BA, Sharma P , Wargo JA .  Cell. 2021; 184(21):5309-5337. PubMed ID:34624224; PMCID:PMC8767569.
Xu L, Peng F, Luo Q, Ding Y, Yuan F, Zheng L, He W, Zhang SS, Fu X, Liu J, Mutlu AS, Wang S, Nehring RB, Li X, Tang Q, Li C, Lv X, Dobrolecki LE, Zhang W, Han D, Zhao N, Jaehnig E, Wang J, Wu W, Graham DA, Li Y, Chen R, Peng W, Chen Y , Catic A, Zhang Z , Zhang B, Mustoe AM, Koong AC , Miles G, Lewis MT, Wang MC, Rosenberg SM, O'Malley BW, Westbrook TF, Xu H , Zhang XH, Osborne CK, Li JB, Ellis MJ, Rimawi MF, Rosen JM, Chen X .  Cell. 2024; 187(25):7248-7266.e34. PubMed ID:39419025; PMCID:PMC11645245.
Pelster MS, Gruschkus SK, Bassett R, Gombos DS , Shephard M, Posada L, Glover MS, Simien R, Diab A , Hwu P , Carter BW , Patel SP .  J Clin Oncol. 2021; 39(6):599-607. PubMed ID:33125309; PMCID:PMC8257877.
Jiang W, Wang Y, Wargo JA , Lang FF , Kim BYS .  Nat Nanotechnol. 2021; 16(1):45823. PubMed ID:33349682; PMCID:PMC8103921.
Lu Y, Huntoon K, Lee D, Wang Y, Ha J, Qie Y, Li X, Schrank BR , Dong S, Gallup TD, Kang M, Zhao H, An Y, Yang Z, Li J , Kim BYS , Jiang W.  Nat Nanotechnol. 2022; 17(12):1332-1341. PubMed ID:36357792; PMCID:PMC10036139.
Wang Y, Deng W, Lee D, Yan L, Lu Y, Dong S, Huntoon K, Antony A, Li X, Ye R, Zhao Y, Zhao F, Schrank BR , Ha J, Kang M, Yang M, Gong P, Lorenzi PL , Tan L, Gallup TD, Tang SK, Yang Z, Li J , Sanford NN, Wang H, Kim BYS , Jiang W.  Nat Nanotechnol. 2024; 19(2):255-263. PubMed ID:37723279; PMCID:PMC12289334.
Glitza IC , Seo YD, Spencer CN, Wortman JR, Burton EM, Alayli FA, Loo CP, Gautam S, Damania A, Densmore J, Fairchild J, Cabanski CR, Wong MC, Peterson CB , Weiner B, Hicks N, Aunins J, McChalicher C, Walsh E, Tetzlaff MT, Hamid O, Ott PA, Boland GM, Sullivan RJ, Grossmann KF, Ajami NJ, LaVallee T, Henn MR, Tawbi HA , Wargo JA.  Cancer Discov. 2024; 14(7):1161-1175. PubMed ID:38588588; PMCID:PMC11215408.
Hao D, Han G, Sinjab A, Gomez-Bolanos LI, Lazcano R, Serrano A, Hernandez SD, Dai E, Cao X, Hu J, Dang M, Wang R, Chu Y, Song X, Zhang J, Parra ER, Wargo JA , Swisher SG , Cascone T , Sepesi B , Futreal AP , Li M, Dubinett SM, Fujimoto J , Solis Soto LM, Wistuba II , Stevenson CS, Spira A, Shalapour S , Kadara H , Wang L .  Cancer Discov. 2022; 12(11):2626-2645. PubMed ID:36098652; PMCID:PMC9633381.
Sinjab A, Han G, Treekitkarnmongkol W, Hara K, Brennan PM, Dang M, Hao D, Wang R, Dai E, Dejima H, Zhang J, Bogatenkova E, Sanchez-Espiridion B, Chang K, Little DR, Bazzi S, Tran LM, Krysan K, Behrens C, Duose DY, Parra ER, Raso MG, Solis LM, Fukuoka J, Zhang J , Sepesi B , Cascone T , Byers LA , Gibbons DL , Chen J , Moghaddam SJ , Ostrin EJ , Rosen D, Heymach JV , Scheet P , Dubinett SM, Fujimoto J , Wistuba II , Stevenson CS, Spira A, Wang L , Kadara H .  Cancer Discov. 2021; 11(10):2506-2523. PubMed ID:33972311; PMCID:PMC8487926.
Wei SC, Meijers WC, Axelrod ML, Anang NAS, Screever EM, Wescott EC, Johnson DB, Whitley E, Lehmann L, Courand PY, Mancuso JJ, Himmel LE, Lebrun-Vignes B, Wleklinski MJ, Knollmann BC, Srinivasan J, Li Y, Atolagbe OT, Rao X, Zhao Y, Wang J , Ehrlich LIR, Sharma P, Salem JE, Balko JM, Moslehi JJ, Allison JP .  Cancer Discov. 2021; 11(3):614-625. PubMed ID:33257470; PMCID:PMC8041233.
Jammihal T, Saliby RM, Labaki C, Soulati H, Gallegos J, Peris A, McCurry D, Yu C, Shah V, Poduval D, El Zarif T, El Ahmar N, Laimon YN, Eid M, Sheshdeh AB, Krajewski KM, B��ttner FA, Schwab M, Heng D, Casellas RC , Rai K , Zacharias Millward NM, Msaouel P , Karam J , Signoretti S, Van Allen E, Choueiri TK, Braun DA, Shukla SA .  Nat Cancer. 2025; 6(2):372-384. PubMed ID:39789182; PMCID:PMC12121501.
Perelli L , Carbone F, Zhang L, Huang JK, Le C, Khan H, Citron F, Del Poggetto E, Gutschner T, Tomihara H, Soeung M, Minelli R, Srinivasan S, Peoples M, Lam TNA, Lundgren S, Xia R, Zhu C, Mohamed AMT, Zhang J, Sircar K, Sgambato A, Gao J , Jonasch E , Draetta GF , Futreal A, Bakouny Z, Van Allen EM, Choueiri T, Signoretti S, Msaouel P , Litchfield K, Turajlic S, Wang L , Chen YB, Di Natale RG, Hakimi AA, Giuliani V, Heffernan TP , Viale A , Bristow CA, Tannir NM , Carugo A, Genovese G .  Nat Cancer. 2023; 4(7):984-1000. PubMed ID:37365326; PMCID:PMC10368532.
Schrank BR , Wang Y, Wu A, Tran N, Lee D, Edwards J, Huntoon K, Dong S, Ha J, Ma Y, Grippin AJ, Jeong SD, Antony A, Chang M, Kang M, Gallup TD, Koong AC , Li J , Yun K, Kim BYS , Jiang W.  Nat Cancer. 2025; 6(3):511-527. PubMed ID:40000910; PMCID:PMC11952976.
Gu M, Zhou X, Sohn JH, Zhu L, Jie Z, Yang JY, Zheng X, Xie X, Yang J, Shi Y, Brightbill HD, Kim JB, Wang J , Cheng X, Sun SC .  Nat Immunol. 2021; 22(2):193-204. PubMed ID:33398181; PMCID:PMC7855506.
Zhou X, Yu J, Cheng X, Zhao B, Manyam GC, Zhang L, Schluns K , Li P, Wang J , Sun SC .  Nat Immunol. 2019; 20(7):879-889. PubMed ID:31182807; PMCID:PMC6588407.
Lee D, Huntoon K, Wang Y, Kang M, Lu Y, Jeong SD, Link TM, Gallup TD, Qie Y, Li X, Dong S, Schrank BR , Grippin AJ, Antony A, Ha J, Chang M, An Y, Wang L, Jiang D , Li J , Koong AC , Tainer JA , Jiang W , Kim BYS .  Nat Biomed Eng. 2024; 8(5):593-610. PubMed ID:38641710; PMCID:PMC11162332.
Wei SC, Sharma R, Anang NAS, Levine JH, Zhao Y, Mancuso JJ, Setty M, Sharma P , Wang J , Pe'er D, Allison JP .  Immunity. 2019; 50(4):1084-1098.e10. PubMed ID:30926234; PMCID:PMC6664799.
Schenkel JM , Pauken KE .  Nat Rev Immunol. 2023; ():. PubMed ID:37253877; PMCID:PMC11448857.
Liu Y, Sinjab A, Min J , Han G, Paradiso F, Zhang Y, Wang R, Pei G, Dai Y, Liu Y, Cho KS, Dai E, Basi A, Burks JK , Rajapakshe KI, Chu Y, Jiang J, Zhang D, Yan X, Guerrero PA, Serrano A, Li M, Hwang TH, Futreal A , Ajani JA , Solis Soto LM, Jazaeri AA , Kadara H , Maitra A , Wang L .  Cancer Cell. 2025; ():. PubMed ID:40154487; PMCID:PMC12074878.
Wang ML , Jain P , Zhao S, Lee HJ , Nastoupil L , Fayad L , Ok CY, Kanagal-Shamanna R , Hill HA, Yao Y, Hagemeister FB, Westin JR , Fowler N , Samaniego F , Steiner R, Nair R , Iyer SP , Navsaria L, Badillo M, Feng L, Xuelin H , Nogueras Gonzalez GM, Xu G, Wagner-Bartak N, Thirumurthi S , Santos D, Tang G, Lin P , Wang SA, Jorgensen J, Yin CC, Li S, Patel KP, Vega F , Medeiros LJ, Flowers CR , Wang L .  Lancet Oncol. 2022; 23(3):406-415. PubMed ID:35074072; PMCID:PMC11937933.
Bhutiani N, Wargo JA .  Nat Rev Clin Oncol. 2022; 19(8):495-496. PubMed ID:35449306.
Thomas AS , Ma W, Wang Y.  N Engl J Med. 2021; 384(6):581-583. PubMed ID:33567198.
Goswami S , Anandhan S, Raychaudhuri D, Sharma P.  Nat Rev Immunol. 2023; 23(2):106-120. PubMed ID:35697799.
Sharma P , Allison JP .  Nat Rev Immunol. 2020; 20(2):75-76. PubMed ID:31925406.
Dummer R, Gyorki DE, Hyngstrom J, Berger AC, Conry R, Demidov L, Sharma A, Treichel SA, Radcliffe H, Gorski KS, Anderson A, Chan E, Faries M, Ross MI .  Nat Med. 2021; 27(10):1789-1796. PubMed ID:34608333.
Helmink BA , Khan MAW, Hermann A, Gopalakrishnan V, Wargo JA . The microbiome, cancer, and cancer therapy. Nat Med. 2019; 25(3):377-388. PubMed ID:30842679.
Park EM, Chelvanambi M, Bhutiani N, Kroemer G, Zitvogel L, Wargo JA .  Nat Med. 2022; 28(4):690-703. PubMed ID:35440726.
Sullivan RJ, Hamid O, Gonzalez R, Infante JR, Patel MR, Hodi FS, Lewis KD, Tawbi HA , Hernandez G, Wongchenko MJ, Chang Y, Roberts L, Ballinger M, Yan Y, Cha E, Hwu P .  Nat Med. 2019; 25(6):929-935. PubMed ID:31171876.
Pei G, Min J , Rajapakshe KI, Branchi V, Liu Y, Selvanesan BC, Thege F , Sadeghian D, Zhang D, Cho KS, Chu Y, Dai E, Han G, Li M, Yee C , Takahashi K, Garg B, Tiriac H, Bernard V, Semaan A, Grem JL, Caffrey TC, Burks JK , Lowy AM, Aguirre AJ, Grandgenett PM, Hollingsworth MA, Guerrero PA, Wang L , Maitra A .  Nature. 2025; 642(8066):212-221. PubMed ID:40269162.
Perelli L , Zhang L, Mangiameli S, Giannese F, Mahadevan KK, Peng F, Citron F, Khan H, Le C, Gurreri E, Carbone F, Russell AJC, Soeung M, Lam TNA, Lundgren S, Marisetty S, Zhu C, Catania D, Mohamed AMT, Feng N, Augustine JJ, Sgambato A, Tortora G, Draetta GF , Tonon G, Futreal A , Giuliani V, Carugo A, Viale A , Kim MP , Heffernan TP , Wang L , Kalluri R , Cittaro D, Chen F, Genovese G .  Nature. 2025; 640(8060):1083-1092. PubMed ID:40044861.
Jiao S, Subudhi SK , Aparicio A , Ge Z, Guan B, Miura Y, Sharma P . . Cell. 2019; 179(5):1177-1190.e13. PubMed ID:31730856.
Sharma P , Goswami S , Raychaudhuri D, Siddiqui BA , Singh P, Nagarajan A, Liu J, Subudhi SK , Poon C, Gant KL, Herbrich SM, Anandhan S, Islam S, Amit M , Anandappa G, Allison JP .  Cell. 2023; 186(8):1652-1669. PubMed ID:37059068.
Sharma P , Siddiqui BA , Anandhan S, Yadav SS, Subudhi SK , Gao J , Goswami S , Allison JP .  Cancer Discov. 2021; 11(4):838-857. PubMed ID:33811120.
Goswami S , Raychaudhuri D, Singh P, Natarajan SM, Chen Y, Poon C, Hennessey M, Tannir AJ, Zhang J, Anandhan S, Kerrigan BP, Macaluso MD, He Z, Jindal S, Lang FF , Basu S, Sharma P .  Nat Cancer. 2023; 4(10):1455-1473. PubMed ID:37653141.
Song B, Wang K, Na S, Yao J, Fattah FJ, Martin AL, von Itzstein MS, Yang DM, Liu J, Xue Y, Liang C, Guo Y, Raman I, Zhu C, Dowell JE, Homsi J, Rashdan S, Yang S, Gwin ME, Wu T, Hsiehchen D, Gloria-McCutchen Y, Lu CP, Raj P, Bai XC, Wang J, Conejo-Garcia J, Xie Y, Huang J, Gerber DE, Wang T.  Nat Cancer. 2025; ():. PubMed ID:40579590.
Goswami S , Pauken KE , Wang L , Sharma P.  Nat Immunol. 2024; 25(12):2186-2199. PubMed ID:39587347.
Raychaudhuri D, Singh P, Chakraborty B, Hennessey M, Tannir AJ, Byregowda S, Natarajan SM, Trujillo-Ocampo A, Im JS , Goswami S.  Nat Immunol. 2024; 25(11):2140-2151. PubMed ID:39375549.
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