Lab Members
Fleming Endowed Professor for Mesothelioma Cancer Research
JZhang20@MDAnderson.org
Department of Thoracic/Head and Neck Medical Oncology
Department of Genomic Medicine
Director of Lung Cancer Interception Program
Ph.D., Chinese Academy of Medical Sciences and Peking Union Medical College, 2002
M.D., Tongji Medical University, 1997
Hong Chen, Ph.D.
Research Scientist
HChen14@MDAnderson.org
Ph.D., Harbin Medical University, 2018
Hong¡¯s research primarily focuses on a comprehensive single-cell transcriptomic analysis that examines the malignant transformation of normal lung tissue to lung adenocarcinoma (LUAD) in mouse models. She is investigating the oncogenic initiation and progression of tumor cells, as well as the dynamic interactions between tumor cells and the tumor microenvironment (TME) over time.
Hui Li, M.D., Ph.D.
Research Scientist
HLi27@MDAnderson.org
M.D., Clinical Medicine, Shanxi Medical University, 2010
Ph.D., Oncology, Peking University, 2015
Hui's research focuses on advancing early detection strategies for lung cancer by evaluating the malignancy risk of pulmonary nodules to enable timely diagnosis and intervention. She also investigates various factors, including biomarkers, that may predict treatment effectiveness and patient prognosis. Her work is dedicated to identifying patients who will benefit most from different therapies (such as chemotherapy, targeted therapy and immunotherapy) with a focus on optimizing personalized treatment approaches to ultimately improve patient outcomes.
Shao-Wei Lu, Ph.D.
Postdoctoral Fellow
SLu5@MDAnderson.org
Ph.D., National Cheng Kung University, 2021
As a postdoctoral fellow, Shao-Wei has been working on lung precancer research, with a focus on understanding the biological and immune mechanisms underlying lung cancer initiation and progression. His research uses preclinical models and molecular and immunological approaches to investigate the evolution of lung precancerous lesions and their interactions with the immune microenvironment, with the goal of identifying potential targets and developing novel strategies for lung cancer interception and prevention.
Yanhua Tian, Ph.D.
Instructor
YTian2@MDAnderson.org
Ph.D., Peking University, 2019
Utilizing cutting-edge technologies, including single cell sequencing and advanced spatial gene and protein analyses, Yanhua is committed to an in-depth exploration of the tumor microenvironment (TME) throughout tumor initiation, invasion and metastasis. By conducting molecular profiling of diverse cellular populations, immune landscapes, and key molecules within the TME, his goal is to unravel the complex dynamics driving tumor progression mechanisms.
Jie Ye, BMed.
Ph.D. Student
JYe1@MDAnderson.org
Jie is investigating intratumor heterogeneity in lung cancer through multi-omics sequencing approaches. Her research focuses on deconvoluting the subclonal architecture of tumor cells to gain insights into the mechanisms driving tumor development and progression.
Bo Zhu, Ph.D.
Instructor
BZhu1@mdanderson.org
Ph.D., Fudan University, 2017
Bo¡¯s research focuses on early-stage lung cancer, utilizing single-cell RNA sequencing, imaging mass cytometry and spatial transcriptomics (including Visium HD, and Xenium) to profile specimens from human and mouse models. His goal is to uncover cancer initiation mechanisms and identify new targets for lung cancer prevention.