Yoon Laboratory
Hojong Yoon, Ph.D.
Principal Investigator
- Departments, Labs and Institutes
- Labs
- Yoon Laboratory
Areas of Research
- Chemical Biology
- Targeted Protein Degradation
- Drug Development
- Biochemistry
- Proteomics
- Structural Biology
- Immunology
The Yoon Lab focuses on developing innovative small-molecule drugs to target previously undruggable proteins and to elucidate drug mechanisms at the molecular level. By integrating chemical biology, protein biochemistry, medicinal chemistry, functional genomics and proteomics, the lab aims to develop new small molecules that induce novel protein-protein interactions, opening new avenues for therapeutic intervention and redefining "druggability."
Featured Publications
Yoon H#, Rutter JC#, Li YD#, Ebert BL. Induced protein degradation for therapeutics: past, present, and future. J Clin Invest. 2024 Jan 2;134(1):e175265. doi: 10.1172/JCI175265. PMID: 38165043
S?abicki M#, Yoon H#, Koeppel J#, Nitsch L, Roy Burman SS, Di Genua C, Donovan KA, Sperling AS, Hunkeler M, Tsai JM, Sharma R, Guirguis A, Zou C, Chudasama P, Gasser JA, Miller PG, Scholl C, Fr?hling S, Nowak RP, Fischer ES, Ebert BL. Small-molecule-induced polymerization triggers degradation of BCL6. Nature. 2020 Dec;588(7836):164-168. doi: 10.1038/s41586-020-2925-1. Epub 2020 Nov 18. PMID: 33208943
Faust TB#, Yoon H#, Nowak RP, Donovan KA, Li Z, Cai Q, Eleuteri NA, Zhang T, Gray NS, Fischer ES. Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15. Nat Chem Biol. 2020 Jan;16(1):7-14. doi: 10.1038/s41589-019-0378-3. Epub 2019 Nov 4. PMID: 31686031
Our Funding
CPRIT Recruitment of First-Time Tenure-Track Faculty Award
(2024¨C)
Â鶹ӳ» MD Anderson Cancer Center Start-up Fund Award
(2025¨C)
UT System Rising STARs award
(2025¨C)
The Allison Institute Research Start-up Funds
(2025¨C)
NIH/NCI 1R00CA287069
(2025¨C)