Xufeng Chen Laboratory
Xufeng Chen, Ph.D.
Principal Investigator
Areas of Research
- Cancer Biology
- CRISPR Screens
- Immunology
- Immunotherapy
- Leukemia
- Mitochondria
- Targeted Therapy
- Tumor Microenvironment
We are interested in understanding the mechanisms of cancer-associated immune evasion, establishing their connections with treatment efficacy and reversing immune evasion to improve treatment outcomes. To achieve this goal, we integrate various cutting-edge experimental and computational approaches in the areas of functional genomics, cell biology, biochemistry, single cell/spatial multi-omics, data mining, drug screening and disease modeling.
Meet Dr. Chen
Assistant Professor, Hematopoietic Biology and Malignancy
Dr. Chen graduated from the University of Chinese Academy of Sciences with a Ph.D. in cell biology and completed postdoctoral training at New York University Langone Medical School. He joined MD Anderson Cancer Center as an assistant professor in March 2025.
Dr. Chen has an excellent track record of highly collaborative and interdisciplinary research in stem cell biology, cancer biology and immunology, as demonstrated by recent first and co-first author papers:
- Stem cell biology: (Chen, Zhang et al., Cell Res, 2014; Zhao, Chen et al., PNAS, 2017; Chen, Zhao et al., Nat Commun, 2018)
- Leukemia biology: (Chen et al., Lancet Haematol, 2018; Chen, Glytsou et al., Cancer Discov, 2019; Glytsou, Chen et al., Cancer Discov, 2023)
- Immunology/ Cancer immunology: (Cui, Chen et al., Cell Rep, 2016; Chen, Lu et al., Cell, 2023; Wang, Qiao, Chen et al., Trends Immunol, 2024)
Wang J*, Qiao L*, Chen X*, Aifantis I. (2024). . Trends Immunol 45(3):177-187. 10.1016/j.it.2024.01.009.
Chen X*, Lu Q*, Zhou H, Liu J, Nadorp B, Lasry A, Sun Z, Lai B, Rona G, Zhang J, et al. (2023). . Cell 186(18):3903-3920.e21. 10.1016/j.cell.2023.07.016.
Glytsou C*, Chen X*, Zacharioudakis E*, Al-Santli W, Zhou H, Nadorp B, Lee S, Lasry A, Sun Z, Papaioannou D, et al. (2023). . Cancer Discov 13, 1656-1677. 10.1158/2159-8290.CD-22-0601.
Chen X*, Glytsou C*, Zhou H, Narang S, Reyna DE, Lopez A, Sakellaropoulos T, Gong Y, Kloetgen A, Yap YS, et al. (2019). . Cancer Discov 9, 890-909. 10.1158/2159-8290.CD-19-0117.
Chen X*, Zhao J*, Gu C, Cui Y, Dai Y, Song G, Liu H, Shen H, Liu Y, Wang Y, et al. (2018). . Nat Commun 9, 3746. 10.1038/s41467-018-06282-2.
Chen X, Aifantis I. (2018). . Lancet Haematol 5, e237-e238. 10.1016/S2352-3026(18)30066-8.
Zhao J*, Chen X*, Song G, Zhang J, Liu H, Liu X. (2017). . Proc Natl Acad Sci U S A 114, E142-E151. 10.1073/pnas.1612967114.
Cui Y*, Chen X*, Zhang J, Sun X, Liu H, Bai L, Xu C, Liu X (2016). . Cell Rep 15, 256-263. 10.1016/j.celrep.2016.03.016.
Chen X*, Zhang J*, Zhao J, Liu H, Sun X, Zhao M, Liu X. (2014). . Cell Res 24, 1013-1016. 10.1038/cr.2014.69.
* indicates co-first author
Contact Us
Contact Dr. Chen:
Email:?XChen25@MDAnderson.org
Phone:?346-725-7027
Office:?South Campus Research Building 2, Room 2SCR4.2022
Mailing Address:
MD Anderson Cancer Center
Hematopoietic Biology and Malignancy
1515 Holcombe Blvd
Unit 0952
Houston,?TX?77030-4009