Singh Laboratory
Harjeet Singh, Ph.D.
Principal Investigator
- Departments, Labs and Institutes
- Labs
- Singh Laboratory
Areas of Research
- Acute Myeloid Leukemia
- Adoptive Cell Therapy
- Bone Cancer
- CAR T-cells
- Immunology
- Immunotherapy
- Leukemia
- Lymphoma
- Targeted Therapy
Our translational research laboratory develops next-generation immune cell therapies for hematologic malignancies and solid tumors. Immunotherapy has transformed cancer treatment by harnessing the body¡¯s own immune system and applying insights from its biology to develop powerful, personalized cell-based therapies. Our laboratory combines immune cell engineering, genetic modification and preclinical modeling ¡ª including chimeric antigen receptor (CAR) and T cell receptor (TCR) platforms, tumor infiltrating lymphocytes (TILs) and single-cell analyses ¡ª to accelerate clinical translation and improve antitumor efficacy.
Our Research Projects
Our current projects include:
- Developing immune cells ¡ª T cells, natural killer (NK) cells, T cell receptor (TCR) gdT cells ¡ª for immunotherapy
- Designing chimeric antigen receptors (CARs) to achieve a fully competent T cell activation signal for efficient efficacy
- Genetic modification and ex vivo expansion of CAR T cells using viral and non-viral methods (Sleeping Beauty system)
- Developing cytokine co-stimulation by expressing membrane bound form of cytokines on T cells
- Establishing efficacy of genetically modified immune cells in mouse models
- Neo-antigen and TCR identification for solid tumors
- Isolation and characterization of tumor infiltrating lymphocytes (TILs) for various solid tumors
- Single cell analysis of immune cells evaluating motility, killing and gene expression analysis
Contact Us
Principal Investigator
Assistant Professor, Pediatrics Research
Email: HSingh@MDAnderson.org
Phone: 713-745-0642
Office Location
Modular Labs (MOD1.021a)
7777 Knight Road
Houston, TX 77054
Mailing Address
MD Anderson Cancer Center
Pediatrics - Research
1515 Holcombe Blvd.
Unit 0853
Houston, TX 77030-4009
, Assistant Professor (left), , Clinical Assistant Professor (middle), Simon Olivares, B.S., Research Laboratory Coordinator (right)
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Research Areas
Find out about the four types of research taking place at UT?MD Anderson.