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Kazutaka Fukumura, Ph.D.
Instructor
KFukumura@MDAnderson.org

I am interested in the elucidation of carcinogenesis mechanisms through genomic analyses.

In the Huse Laboratory, I perform comprehensive genomic analysis of glioma and brain metastasis with the aim of developing novel therapeutic strategies against these refractory cancers.

Prit Benny Malgulwar, Ph.D.
Instructor
PMalgulwar@MDAnderson.org

I incorporate data analysis and molecular tools to establish genetic-epigenetic network in gliomas, with focus on ATRX alterations at bulk and single cell resolution and targeting?this network using pharmco-(epi)genomic approach for reversal phenotype. To understand this paradigm, I am utilizing high-throughput chromatin sequencing technologies, including genome-wide chromatin contact maps that captures the three-dimensional (3D) organizational structure of chromatin. Our goal is to characterize the perturb chromatin structures in 3-D space, to understand in-depth stochastic mechanism of gliomas in order to define disease-state and its regulatory mechanism. In addition to this, I am also involved in understanding molecular fingerprint of brain metastasis tumors using various genomic platform, where I am handling high-throughput data analysis.