Lab Members
Principal Investigator
Research in the Gopalakrishnan Lab is directed towards identifying novel therapeutic targets for medulloblastoma, a pediatric brain tumor. A major focus of the research involves the study of developmental signals required for normal cerebellar development as a means to understand the molecular basis and pathophysiology of medulloblastoma. A second major goal of the research is to identify epigenetic alterations of gene expression in pediatric brain tumors and determine the therapeutic efficacy of drugs that reverse these changes in mouse models of brain tumors.
Associate Professor
Dong studies the role of arginine methylation in the development of pediatric brain tumors. He is experienced with genetically engineered mouse models and biochemical techniques.
Shu Feng, Ph.D.
Research Investigator
Feng has expertise with brain tumor surgery and maintains the Gopalakrishnan Lab patient-derived xenograft models of pediatric brain tumors.
Swarnalatha Manickavinayaham, Ph.D.
Research Scientist
Manickavinayahar's research is focused on defining the repressive epigenome of pediatric diffuse midline glioma and identifying druggable opportunities.?
Jyothishmathi Swaminathan, Ph.D.
Research Scientist
Jyo studies chromatin organization during cell fate transitions in neural stem cells and determines how its mis-organization drives aberrant expression of immune modulatory genes and tumorigenesis.
Ashutosh Singh, Ph.D.
Postdoctoral Fellow
Ashutosh investigates the role of protein ubiquitination during neurogenesis and tumor progression. He employs biochemical techniques for in vitro studies and uses genetically engineered mice and xenograft models to study tumor development.
Yanwen Yang
Laboratory Manager
Yanwen assists with onboarding personnel. He is an expert in cell and molecular biology and performs high-throughput epigenetic screens.