Gautier Laboratory
Jean Gautier, Ph.D., Dr.Sc.
Principal Investigator
Areas of Research
- Genome Stability
- DNA Repair
- Chromatin
- Nuclear Actin
- DNA Damage Response
Welcome to the Gautier Laboratory at MD Anderson. We are defining the mechanisms that preserve genome integrity in normal cells and elicit genome instability in cancer cells. Our work centers on repair mechanisms that rely on nuclear architecture and genome organization during physiological DNA transactions for proper execution, such as transcription, replication and recombination.
Our Research
The Gautier Lab¡¯s research program centers on how the 3D organization of the genome facilitates and coordinates DNA repair alongside other DNA-templated processes, including DNA replication and transcription. We study this to better understand how dysregulation in these processes contributes to pathological genomic rearrangements and cancer development, as well as the therapeutic implications of such rearrangements. The lab employs cutting edge technologies in microscopy, genomics, proteomics and computational biology to advance their research.
