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Publications

 Development of a corticosteroid-immunosuppressed mouse model to study the pathogenesis and therapy of influenza-associated pulmonary aspergillosis. J Infect Dis. 2023 Jan 6:jiad001. doi: 10.1093/infdis/jiad001. Epub ahead of print. PMID: 36611269.
. SARS-CoV-2 Infection: Host Response, Immunity, and Therapeutic Targets. Inflammation 45(4):1430-1449, 2022. e-Pub 2022. PMID: 35320469.
 Epithelial immunomodulation by aerosolized Toll-like receptor agonists prevents allergic inflammation in airway mucosa in mice. Front Pharmacol. 2022 Aug 29;13:833380. doi: 10.3389/fphar.2022.833380. PMID: 36105216.
. Summary for Clinicians: Clinical Practice Guideline for the Use of Nucleic Acid-based Testing for Noninfluenza Viral Pathogens in Adults with Suspected Community-acquired Pneumonia. Ann Am Thorac Soc 19(7):1081-1083, 2022. e-Pub 2022. PMID: 35353672.
. OBIF: an Omics-based interaction framework to reveal molecular drivers of synergy. NAR Genom Bioinform 4(2):lqac028, 2022. e-Pub 2022. PMID: 35387383.
. Selective Modulation of the Pulmonary Innate Immune Response Does not Change Lung Microbiota in Healthy Mice. Am J Respir Crit Care Med 204(6):734-736, 2021. e-Pub 2021. PMID: 34153197.
. Repetitive aeroallergen challenges elucidate maladaptive epithelial and inflammatory traits that underpin allergic airway diseases. J Allergy Clin Immunol 148(2):533-549, 2021. e-Pub 2021. PMID: 33493557.
. Targeting the Hypoxia-Adenosine Link for Controlling Excessive Inflammation. Anesthesiology 135(1):15-17, 2021. e-Pub 2021. PMID: 34046661.
. Understanding the Host in the Management of Pneumonia. An Official American Thoracic Society Workshop Report. Ann Am Thorac Soc 18(7):1087-1097, 2021. PMID: 34242148.
. Antifungal Prophylaxis for Adult Recipients of Veno-Venous Extracorporeal Membrane Oxygenation: A Cautionary Stance During the COVID-19 Pandemic. ASAIO J 67(6):611-613, 2021. e-Pub 2021. PMID: 33769344.
. Pulse oximetry is an essential tool that saves lives: a call for standardisation. Eur Respir J 57(6), 2021. e-Pub 2021. PMID: 34088755.
. Nucleic Acid-based Testing for Noninfluenza Viral Pathogens in Adults with Suspected Community-acquired Pneumonia. An Official American Thoracic Society Clinical Practice Guideline. Am J Respir Crit Care Med 203(9):1070-1087, 2021. PMID: 33929301.
. Immune Modulation to Improve Survival of Viral Pneumonia in Mice. Am J Respir Cell Mol Biol 63(6):758-766, 2020. e-Pub 2020. PMID: 32853024.
. Management of Community-Acquired Pneumonia in Immunocompromised Adults: A Consensus Statement Regarding Initial Strategies. Chest 158(5):1896-1911, 2020. e-Pub 2020. PMID: 32561442.
. Inducible Epithelial Resistance Against Coronavirus Pneumonia in Mice. Am J Respir Cell Mol Biol 63(4):540-541, 2020. e-Pub 2020. PMID: 32706609.
. Mediastinal lymphadenitis due to Nocardia infection. J Bronchology Interv Pulmonol 27(3):e48-e51, 2020. PMID: 32569081.
. COVID-19: a case for inhibiting IL-17?. Nat Rev Immunol 20(6):345-346, 2020. e-Pub 2020. PMID: 32358580.
. Inducible epithelial resistance against acute Sendai virus infection prevents chronic asthma-like lung disease in mice. Br J Pharmacol 177(10):2256-2273, 2020. e-Pub 2020. PMID: 31968123.
. Antibiotic Stewardship in the Intensive Care Unit. An Official American Thoracic Society Workshop Report in Collaboration with the AACN, CHEST, CDC, and SCCM. Ann Am Thorac Soc 17(5):531-540, 2020. PMID: 32356696.
. A molecularly engineered antiviral banana lectin inhibits fusion and is efficacious against influenza virus infection in vivo. Proc Natl Acad Sci U S A 117(4):2122-2132, 2020. e-Pub 2020. PMID: 31932446.
. Distinct immunophenotypes of T cells in bronchoalveolar lavage fluid from leukemia patients with immune checkpoint inhibitors-related pulmonary complications. Front Immunol 11:590494, 2020. e-Pub 2021. PMID: 33552049.
. Summary for Clinicians: Microbiological Laboratory Testing in the Diagnosis of Fungal Infections in Pulmonary and Critical Care Practice. Ann Am Thorac Soc 16(12):1473-1477, 2019. PMID: 31526275.
. Lipocalin-2 is dispensable in inflammation-induced sickness and depression-like behavior. Psychopharmacology (Berl) 236(10):2975-2982, 2019. e-Pub 2019. PMID: 30806746.
. Diagnosis of Fungal Infections: A Systematic Review and Meta-Analysis Supporting ATS Clinical Practice Guideline. Ann Am Thorac Soc 16(9):1179-1188, 2019. e-Pub 2019. PMID: 31219341.
. Microbiological Laboratory Testing in the Diagnosis of Fungal Infections in Pulmonary and Critical Care Practice. An Official American Thoracic Society Clinical Practice Guideline. Am J Respir Crit Care Med 200(5):535-550, 2019. PMID: 31469325.
. Refinement of estimates of mortality risk using the Radiologic Severity Index in hematologic malignancy patients with respiratory syncytial virus infection. Transpl Infect Dis 21(4):e13105, 2019. e-Pub 2019. PMID: 31081570.
. MAGI1 as a link between endothelial activation and ER stress drives atherosclerosis. JCI Insight 4(7), 2019. e-Pub 2019. PMID: 30944250.
. Inducible lung epithelial resistance requires multisource reactive oxygen species generation to protect against bacterial infections. PLoS One 14(2):e0208216, 2019. e-Pub 2019. PMID: 30794556.
. Progression of the Radiologic Severity Index is associated with increased mortality and healthcare resource utilisation in acute leukaemia patients with pneumonia. BMJ Open Respir Res 6(1):e000471, 2019. e-Pub 2019. PMID: 31921429.
. Sex specific function of epithelial STAT3 signaling in pathogenesis of K-ras mutant lung cancer. Nat Commun 9(1):4589, 2018. e-Pub 2018. PMID: 30389925.
. Bronchoalveolar lavage fluid cytology in culture-documented invasive pulmonary aspergillosis in patients with hematologic diseases: analysis of 67 episodes. J Clin Microbiol 56(10), 2018. e-Pub 2018. PMID: 30021823.
. Future Research Directions in Pneumonia: NHLBI Working Group Report. Am J Respir Crit Care Med 198(2):256-263, 2018. e-Pub 2018. PMID: 29546996.
. IL-22 promotes K-ras mutant lung cancer by induction of a pro-tumor immune response and protection of stemness properties. Cancer Immunol Res 6(7):788-797, 2018. e-Pub 2018. PMID: 29764837.
. Inducible lung epithelial resistance requires multisource reactive oxygen species generation to protect against viral infections. MBio 9(3), 2018. e-Pub 2018. PMID: 29764948.
. Lung epithelial cells: therapeutically inducible effectors of antimicrobial defense. Mucosal Immunol 11(1):21-34, 2018. e-Pub 2017. PMID: 28812547.
. Combined aerosolized Toll-like receptor ligands are an effective therapeutic agent against influenza pneumonia when co-administered with oseltamivir. Eur J Pharmacol 818:191-197, 2018. e-Pub 2017. PMID: 29066417.
. Progression of the radiologic severity index predicts mortality in patients with parainfluenza virus-associated lower respiratory infections. PLoS One 13(5):e0197418, 2018. e-Pub 2018. PMID: 29771962.
. Inducible epithelial resistance protects mice against leukemia-associated pneumonia. Blood 128(7):982-92, 2016. e-Pub 2016. PMID: 27317793.
. Sleep disordered breathing as a delayed complication of iatrogenic vocal cord trauma. Sleep Med 22:1-3, 2016. e-Pub 2016. PMID: 27544828.
. The development and plasticity of alveolar type 1 cells. Development 143(1):54-65, 2016. e-Pub 2015. PMID: 26586225.
. Assessing compliance with established pneumonia core measures at a comprehensive cancer center. J Healthc Qual 37(4):232-44, 2015. e-Pub 2014. PMID: 24629128.
. Microbiological and clinical studies of legionellosis in 33 patients with cancer. J Clin Microbiol 53(7):2180-7, 2015. e-Pub 2015. PMID: 25926494.
. Porous silicon microparticle potentiates anti-tumor immunity by enhancing cross-presentation and inducing type I interferon response. Cell Rep 11(6):957-66, 2015. e-Pub 2015. PMID: 25937283.
. Predicting pneumonia mortality using CURB-65, PSI, and patient characteristics in patients presenting to the emergency department of a comprehensive cancer center. Cancer Med 3(4):962-70, 2014. e-Pub 2014. PMID: 24802800.
. Lung epithelial cells are essential effectors of inducible resistance to pneumonia. Mucosal Immunol 7(1):78-88, 2014. e-Pub 2013. PMID: 23632328.
. Muc5b is required for airway defence. Nature 505(7483):412-6, 2014. e-Pub 2013. PMID: 24317696.
. Safety, tolerability, and biomarkers of the treatment of mice with aerosolized toll-like receptor ligands. Front Pharmacol 5:8, 2014. e-Pub 2014. PMID: 24567720.
. Pneumonia during remission induction chemotherapy in patients with acute leukemia. Ann Am Thorac Soc 10(5):432-40, 2013. e-Pub 2013. PMID: 23987587.
. Deletion of the gene encoding calcitonin and CGRP�� does not affect the outcome of severe infection in mice. Am J Respir Cell Mol Biol 49(1):151-5, 2013. e-Pub 2013. PMID: 23526213.
. TLR2/6 and TLR9 agonists suppress viral replication but not airway hyperreactivity in guinea pigs. Am J Respir Cell Mol Biol 48(6):790-6, 2013. e-Pub 2013. PMID: 23449736.
. Primary alveolar epithelial cell surface membrane microdomain function is required for Pneumocystis ��-glucan-induced inflammatory responses. Innate Immun 18(5):709-16, 2012. e-Pub 2012. PMID: 22334619.
. Synergistic TLR2/6 and TLR9 activation protects mice against lethal influenza pneumonia (***Top 10% most cited papers for this journal***). PLoS One 7(1):e30596, 2012. e-Pub 2012. PMID: 22299046.
. Performance of a standardized bronchoalveolar lavage protocol in a comprehensive cancer center: A prospective 2-year study. Cancer 117(15):3424-33, 2011. e-Pub 2011. PMID: 21246537.
. Inhaled innate immune ligands to prevent pneumonia. Br J Pharmacol 163(1):195-206, 2011. e-Pub 2011. PMID: 21250981.
. Synergistic interactions of TLR2/6 and TLR9 induce a high level of resistance to lung infection in mice. J Immunol 186(10):5916-26, 2011. e-Pub 2011. PMID: 21482737.
. Interleukin 6 but not T helper 2 cytokines promotes lung carcinogenesis. Cancer Prev Res (Phila) 4(1):51-64, 2011. e-Pub 2010. PMID: 21098042.
. Stimulated innate resistance of lung epithelium protects mice broadly against bacteria and fungi. Am J Respir Cell Mol Biol 42(1):40-50, 2010. e-Pub 2009. PMID: 19329554.
. Augmented lung inflammation protects against influenza A pneumonia. PLoS One 4(1):e4176, 2009. e-Pub 2009. PMID: 19137067.
. Allergic lung inflammation alters neither susceptibility to Streptococcus pneumoniae infection nor inducibility of innate resistance in mice. Respir Res 10(10):70, 2009. PMID: 19635139.
. Stimulation of lung innate immunity protects against lethal pneumococcal pneumonia in mice. Am J Respir Crit Care Med 177(12):1322-30, 2008. e-Pub 2008. PMID: 18388354.
. (Cover Article) Pneumocystis cell wall ��-glucans stimulate alveolar epithelial cell chemokine generation through nuclear factor-?B-dependent mechanisms. Am J Respir Cell Mol Biol 32(6):490-7, 2005. e-Pub 2005. PMID: 15746433.
. Evaluation of right pulmonary artery obstruction by echocardiography in a 32-year-old woman with suggested histoplasmosis. J Am Soc Echocardiogr 18(5):490-1, 2005. PMID: 15891762.
. Transforming growth factor-��1 and extracellular matrix-associated fibronectin expression in pulmonary lymphangioleiomyomatosis. Chest 125(3):1063-70, 2004. PMID: 15006970.
. Pneumocystis carinii: cell wall ��-glucan-mediated pulmonary inflammation. J Eukaryot Microbiol 50 Suppl:646, 2003. PMID: 14736200.
. Pneumocystis carinii cell wall ��-glucan induces release of macrophage inflammatory protein-2 from alveolar epithelial cells via a lactosylceramide-mediated mechanism. J Biol Chem 278(3):2043-50, 2003. PMID: 12419803.
. Host lung gene expression patterns predict infectious etiology in a mouse model of pneumonia. Respir Res 11(1):101. e-Pub 2010. PMID: 20653947.
. Toll-deficient Drosophila are resistant to infection by Pneumocystis spp.: additional evidence of specificity to mammalian hosts. Virulence 1(6). e-Pub 2010. PMID: 21178507.
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