Symptom Research Projects
In pursuit of its goals, the Department of Symptom Research employs a translational approach that ranges from bench to bedside and from bedside to bench. Our cross-cutting program integrates both preclinical and clinical research:
- Preclinical and translational research: The department's four Neuroimmunology Laboratories are conducting animal and in vitro studies to discover molecular and cellular mechanisms underlying the symptoms that develop in response to cancer and its treatment ¡ª for example, cognitive impairment, pain and fatigue. We are pursuing regenerative medicine and novel agents for treating neurotoxic symptoms.
- Clinical research: The department's Patient-Centered Analytics section engages in observational and interventional studies focused on educational, behavioral and medical interventions for cancer-related and treatment-related symptoms; creates methodologies for designing, validating, and deploying patient-reported outcomes assessment questionnaires; and develops innovative approaches that use machine learning and artificial intelligence to assess, analyze and predict patient outcomes.
Neuroimmunology
Laboratories
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Dantzer Lab
Researching the mechanisms of inflammation-induced sickness and depression-like behavior and cancer-related fatigue
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Grace Lab
Investigating adaptive immune mechanisms that initiate and maintain neuropathic pain after traumatic nerve injury
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Yuan Pan Lab
Seeking insights into the prediction, prevention, and treatment of nervous system cancer and neurological disorders
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Shepherd Lab
Investigating tumor-immune interactions in chemotherapy-induced peripheral neuropathy and musculoskeletal pain
Patient-Centered
Analytics
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Large Data Computation: AI & Machine Learning
Aligning cross-cutting methodologies (AI, data science, and patient-centered outcomes) in clinical practice/research
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Symptom Measurement: Surveys & Methodology
Developing and validating symptom assessment questionnaires in various languages and developing methods for their use
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Cancer-Related Symptom Burden
Using patient-reported outcomes to study symptoms, quality of life, and preferences for symptom control
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Cancer Treatment-Related Toxicity
Investigating the symptomatic and toxic effects of various therapies