Research
The focus of research in Bioinformatics and Computational Biology is microarray data analysis, reverse-phase protein array analysis, biomarker identification, drug target discovery, functional genomics and proteomics, coding sequence analysis, cross-validation analysis, forensic applications of genetics and the analysis of genetic trait inheritance. Other areas of specialization include analyzing the effects of radiotherapy, cell population dynamics, molecular confirmation studies, modeling biological processes, computer-assisted diagnosis, computer-assisted image interpretation, statistical graphics, and the analysis of cell cycle regulatory proteins.
Our faculty carry out independent research to develop and improve the quantitative science that underlies bioinformatics tools and methods. The tools and software they develop are freely available.
Current faculty projects:
- Genome Data Analysis Center, as part of The Cancer Genome Atlas project of the National Institutes of Health (NIH)
- Combining drug sensitivity results with gene expression profiles
- Discovering and validating cancer signatures in reverse-phase protein lysate array (RPPA) data
- Better quantifications and processing of RPPA data
- Analysis of methylation arrays
- Â鶹ӳ»ing for alternative splicing using exon arrays
- Sample size computations for microarray and proteomics profiling experiments
- Low-level processing of mass spectrometry proteomics data
Bioinformatics Shared Resource
The Bioinformatics Shared Resource (BISR) provides consultative services for and conducts collaborative research with clinical and basic science departments and enhances quantitative methods through innovative research in genomics, proteomics, molecular and cellular biology, radiotherapy, computer-assisted diagnoses and image analysis. It is partially funded by the National Cancer Institute, National Institutes of Health, through the Cancer Center Support Grant, P30 CA016672.
Learn more about the Bioinformatics Shared Resource
Collaboration/Support
Turnaround times vary depending on the size and scope of the project. You should anticipate a minimum of two weeks, but it is best to contact the BISR at the following times:
- as you are starting to plan your research protocol
- at least two weeks before an abstract submission for a meeting or conference is due
- at least four weeks before an R01 grant proposal is due
- at least 16 weeks before a P01 grant proposal is due
- at least 16 weeks before a SPORE grant proposal is due
For an initial consultation, bring the following:
- The name of the primary (or principal) investigator
- The name of the project
- Grant number associated with your research project (if funded through a grant)
- Any information, including preliminary data, that will help to explain the project and the science that motivates it
Fee: The BISR does not charge a fee for its service. However, co-authorship on manuscripts and salary support through the PI¡¯s funding mechanism (when applicable) are requested.