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Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a leukemia so rare that it affects only between 500 and 1,000 people in the U.S. each year. It is usually found in males in their late 60s or early 70s, but it can occur in people of any age or gender.

BPDCN was originally thought to be a type of lymphoma, but it¡¯s now considered a subtype of leukemia. It is frequently misdiagnosed because it combines features of leukemia,...