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Kidney cancers don¡¯t generally cause pain in patients before diagnosis. That¡¯s because the most common types of kidney cancer tend to grow very slowly, so they gently push other organs aside as they get larger.

But what does kidney cancer pain feel like? And what causes the rest of the sensations people often describe as ¡°kidney pain?¡± Read on to find out.

Kidney cancer pain is dull, achy and persistent

Only about 10% of patients with kidney cancer report experiencing flank or abdominal pain as a symptom of the disease. When they do, it¡¯s usually described as a dull, persistent ache that worsens over time, rather than a sudden, sharp pain.

That¡¯s because the kidney capsule ¡ª or outermost layer of tissue covering the organ ¡ª is the part that contains the most nerve endings.?

So, unless something like sudden bleeding within a tumor quickly stretches out the kidney capsule, there is no such thing as true kidney cancer pain. However, if a kidney tumor spreads to other organs such as the bone, it can sometimes cause bone pain.

Another reason patients might experience pain in the kidney area is when bleeding flows down a ureter and causes an obstruction there with clots. But I¡¯ve seen patients with kidney tumors up to 25 cm (almost 10 inches) wide, and yet they report no pain.?

Reasons for other types of ¡®kidney¡¯ pain

Pain in the abdomen or flank, on the other hand, can be attributed to many different causes, including several non-cancerous conditions. These include:

• Kidney stones
• Musculoskeletal problems
• Pyelonephritis: a urinary tract infection in the kidney
• Hydronephrosis: when a ureter is blocked by a kidney stone or pinched shut in some other way, causing a backup of urine
• Polycystic kidney disease: a genetic condition that causes both kidneys to become filled with innumerable cysts
• Renal vein thrombosis: a rare type of clot that can obstruct the flow of blood from the kidney

But kidney cancer pain is a very different type of pain from the kind people typically experience with any of these other conditions. The severe, sudden pain of a kidney stone passing, for instance, stems from the ureter being stretched out as the stone makes its way down that tube to the bladder.

When to get ¡®kidney pain¡¯ checked out

Unfortunately, no screening test currently exists for kidney cancer. So, there¡¯s no blood test, urine test, or imaging scan we can do to detect it early in the average person. That¡¯s why you should have any persistent pain in your abdomen or flank checked out by a physician for a formal diagnosis.?

However, most bladder cancers are detected through blood in the urine. So, blood in the urine should absolutely not be ignored. And, anyone who experiences it should be evaluated by a urologist. Any blood in the urine should also be considered serious until proven otherwise.

, is a urologic surgeon specializing in kidney and other genitourinary cancers.

or call 1-877-632-6789.

Renal medullary carcinoma (RMC) is a rare and extremely aggressive kidney cancer. In the United States, it is diagnosed most frequently among young Black men who carry the sickle cell trait, an inherited blood mutation.

But do you have to carry the sickle cell trait to develop renal medullary carcinoma? How else does it differ from other kidney cancers? And, what are the latest advances in its diagnosis and treatment?

Here, medical oncologist , answers these and other questions about renal medullary carcinoma.

Do you have to carry the sickle cell trait to be at risk for renal medullary carcinoma?

No. Most people who are diagnosed with it will carry the mutation, but between 5% and 10% of all renal medullary carcinoma cases are not associated with that trait.

How does renal medullary cancer differ from other kidney cancers?

The biggest difference is in its treatment. Almost every single strategy developed for garden variety kidney cancer does not work with renal medullary carcinoma. In fact, they often make it worse.?

With most early-stage kidney cancers, for instance, you can start with surgery, if a tumor is small enough. But in most renal medullary carcinoma cases, you need to start with chemotherapy.

That¡¯s because most kidney cancers do not spread to the lymph nodes nearly as much as renal medullary carcinoma does. Renal medullary carcinoma loves to spread to lymph nodes, and it does so at a much higher rate than any other kidney cancer.

So, even if imaging isn¡¯t showing renal medullary carcinoma in your lymph nodes, it¡¯s probably there if you have it in your kidney. But a surgeon will typically only discover that after the fact. Also, we can¡¯t know if chemotherapy is working unless we can track a tumor¡¯s response to it over time on imaging. That¡¯s why it¡¯s so important to start treatment for RMC with chemotherapy first.

Finally, the right kidney tends to be more susceptible to renal medullary carcinoma than the left. We believe this is because the artery that supplies the right kidney is longer, so it takes more time for the blood to get there. There¡¯s also more resistance with a longer tube, so there¡¯s less blood flow in the right kidney's artery. That makes it more prone to infarcts, or tissue damage caused by a lack of oxygen.

Are the symptoms of renal medullary carcinoma any different from those of other kidney cancers?

No, not really. Hematuria, or blood in the urine, is the most common symptom of renal medullary carcinoma. But it can also be a symptom of all kidney cancers. We see it in about 60% of our renal medullary carcinoma patients here at MD Anderson.?

Pain is the second-most common symptom. We see it in a little less than half of all renal medullary carcinoma cases. Again, pain can be a symptom of all kidney cancers. In RMC, it¡¯s usually on the side that has the cancer, most often on the right.?

Less common symptoms include belly pain and weight loss. But those only happen in about 20% of our patients with renal medullary carcinoma.

Why should people choose MD Anderson for their renal medullary carcinoma treatment?

Renal medullary carcinoma is very, very rare, so most clinicians will only see one case of it in their entire careers, if that. But my mentor, genitourinary medical oncologist , started building our program more than a decade ago, after a patient of his died of the disease. That program, which I now lead, has a lab that works exclusively on renal medullary carcinoma.

I¡¯d also estimate that I personally help manage more than 80% of all renal medullary carcinoma cases in the world. Doctors reach out to me from as far away as New Zealand, Germany, Greece and Norway for guidance, and I¡¯m always happy to provide it.

Another reason to choose MD Anderson is that, with treatment, we render up to 10% of our patients with stage IV renal medullary carcinoma cancer-free, which was thought to be impossible five years ago. MD Anderson was also the first to design a clinical trial just for renal medullary carcinoma and the first to get any funding for its research.

We¡¯ve increased the average length of survival after a renal medullary carcinoma diagnosis, too. Back when it was first described in 1995, patients typically only survived about four months after their diagnosis. By 2017, the average survival had improved to 13 months. But research has really accelerated since 2018, and now it¡¯s at least 18 months. Our goal is to extend that to two years by 2025, and to five years by 2030. We¡¯re on pace to get there.

What are the most exciting advances in renal medullary carcinoma research?

We¡¯ve always got at least one clinical trial available for renal medullary carcinoma patients. But our latest, which opened Sept. 1, is designed to harness the immune system in a better way to target CA-125, a chemical marker normally seen in ovarian cancer. My lab discovered that it¡¯s also expressed by renal medullary carcinoma. Another rare cancer called epithelioid sarcoma, which has the same molecular driver as renal medullary carcinoma, also expresses CA-125.

Until 2012, we only had one standard therapy for RMC: carboplatin plus paclitaxel. Then, we established a second-line therapy that used gemcitabine and doxorubicin, either alone or in combination with ixazomib. Later, we established a third-line therapy that targets the EFGR pathway with panitumumab, carboplatin and nab-paclitaxel. And now, we have clues for a fourth-line therapy that targets the TROP2 pathway.

In May 2022, I was reviewing some experiments in my lab and started noticing certain patterns. I discussed them with , who is a breast medical oncologist here at MD Anderson, and she had the idea to try a targeted therapy against the EGFR pathway first used to treat breast cancer. Within a week, we had repurposed that therapy for a patient with stage IV renal medullary carcinoma, and he¡¯s still responding well to it today. Since that time, this combination of panitumumab, carboplatin and nab-paclitaxel has been given to more than 20 people with renal medullary carcinoma around the world.

or call 1-877-632-6789.